PS-432( PS432 )

Catalog No. M13247 CAS No. 2083630-26-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PS-432
Note

Research use only, not for human use.
Brief Description

PS-432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively.
Description

PS-432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively; has no inhibitory activity against PKCα, PKCβ, PKCδ and PKCθ nor the activity of related kinases such as PDK1, PKB/Akt, RSK1, MSK1 and Aurora A; inhibits the proliferation of the lung cancer cell lines A549 (IC50=14.8 ± 4.2 uM) and A427 (IC50=10.4± 0.3 uM) as well as androgen-independent prostate cancer cell line DU145 (IC50 = 20.8 ± 9.0 uM); well tolerated in vivo.
In Vitro

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In Vivo

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Synonyms

PS432
Pathway

Angiogenesis
Target

PKC
Recptor

PKC
Research Area

——
Indication

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CAS Number

2083630-26-4
Formula Weight

494.946
Molecular Formula

C25H19ClN2O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (202.04 mM)
SMILES

O=C(C1=C(O)C(N(C2=NC3=CC=C(C)C=C3S2)C1C4=CC=C(C5=CC=C(Cl)C=C5)O4)=O)OCC
Chemical Name

ethyl 2-(5-(4-chlorophenyl)furan-2-yl)-4-hydroxy-1-(6-methylbenzo[d]thiazol-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate

1. Arencibia JM, et al. ACS Chem Biol. 2017 Feb 17;12(2):564-573.

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