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MC2884
CAS No. 330657-42-6
MC2884( MC 2884 | MC-2884 )
Catalog No. M14097 CAS No. 330657-42-6
MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMC2884
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NoteResearch use only, not for human use.
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Brief DescriptionMC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.
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DescriptionMC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively; induces caspase- and mitochondrial-dependent cancer-selective apoptosis on a variety of cancers, accompanied by ROS production; displays anticancer action in both hematological and solid cancer in vivo models, induces apoptosis in aggressive cancers and in primary leukemic blasts, also synergizes with BCL2 inhibitors.
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In Vitro——
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In Vivo——
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SynonymsMC 2884 | MC-2884
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PathwayChromatin/Epigenetic
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TargetHAT
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RecptorHAT
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Research Area——
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Indication——
Chemical Information
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CAS Number330657-42-6
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Formula Weight523.268
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Molecular FormulaC26H21Br2NO
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-benzyl-3,5-bis((E)-3-bromobenzylidene)piperidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petraglia F, et al. Oncotarget. 2018 May 22;9(39):25630-25646.
2. Singh AA, et al. Oncotarget. 2018 May 22;9(39):25647-25660.
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