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OBP-801
CAS No. 328548-11-4
OBP-801( OBP801 | YM 753 | Spiruchostatin A )
Catalog No. M14075 CAS No. 328548-11-4
OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | Get Quote |
|
| 50MG | 3042 | Get Quote |
|
| 100MG | 4140 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOBP-801
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NoteResearch use only, not for human use.
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Brief DescriptionOBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.
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DescriptionOBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM; significantly inhibits the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim; significantly suppresses tumor growth in vivo.Kidney Cancer Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsOBP801 | YM 753 | Spiruchostatin A
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaCancer
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IndicationKidney Cancer
Chemical Information
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CAS Number328548-11-4
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Formula Weight473.603
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Molecular FormulaC20H31N3O6S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C[C@H](O2)/C=C/CCSSC[C@@H](NC([C@@H](C)N1)=O)C(N[C@H](C(C)C)[C@@H](O)CC2=O)=O
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Chemical Name(1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shindoh N, et al. Int J Oncol. 2008 Mar;32(3):545-55.
2. Yoshioka T, et al. Gynecol Oncol. 2013 May;129(2):425-32.
3. Furutani A, et al. Oncol Res. 2014;21(5):281-6.
4. Akiyama M, et al. Oncol Res. 2017 Sep 21;25(8):1245-1252.
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