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Home - Products - Membrane Transporter/Ion Channel - GAT - Indiplon

Indiplon

CAS No. 325715-02-4

Indiplon( NBI-34060 )

Catalog No. M14055 CAS No. 325715-02-4

A potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Indiplon
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site.
  • Description
    A potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively); potentiates the GABA-activated chloride current in recombinant GABA(A) receptors in a dose-dependent and reversible manner in 293 cells, 10-fold selective for α1 subunit-containing receptors over GABA(A) receptors containing α2, α3, or α5 subunits. Sleep Disorder Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NBI-34060
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    325715-02-4
  • Formula Weight
    376.4316
  • Molecular Formula
    C20H16N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(N(C)C1=CC=CC(C2=CC=NC3=C(C(C4=CC=CS4)=O)C=NN23)=C1)=O
  • Chemical Name
    Acetamide, N-methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lankford A. Neuropsychiatr Dis Treat. 2007 Dec;3(6):765-73. 2. Marrs JC. Ann Pharmacother. 2008 Jul;42(7):1070-9. 3. Petroski RE, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):369-77.
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