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inh-02
CAS No. 324579-65-9
inh-02( RNF5 inhibitor inh-02 )
Catalog No. M14053 CAS No. 324579-65-9
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 188 | In Stock |
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| 5MG | 180 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 655 | In Stock |
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| 50MG | 1097 | In Stock |
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| 100MG | 1841 | In Stock |
|
| 200MG | 2492 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Nameinh-02
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NoteResearch use only, not for human use.
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Brief Descriptioninh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.
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Descriptioninh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5.
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In Vitro——
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In Vivo——
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SynonymsRNF5 inhibitor inh-02
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number324579-65-9
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Formula Weight384.501
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Molecular FormulaC23H20N4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (216.72 mM)
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SMILES——
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Chemical Name(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sondo E, et al. Cell Chem Biol. 2018 Apr 26. pii: S2451-9456(18)30124-7.
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