Tegafur

Research use only, not for human use.

A chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers; a thymidylate synthase inhibitor.

A chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers; a thymidylate synthase inhibitor. Chemotherapeutic Agents Approved(In Vitro):Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.

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5-Fluoro-1-(tetrahydro-2-furfuryl)uracil | Ftorafur | NSC 148958 | TS-1

Cell Cycle/DNA Damage

Nucleoside Antimetabolite/Analog

DNAsynthesis

Cancer

Chemotherapeutic

17902-23-7

200.1671

C8H9FN2O3

>98% (HPLC)

DMSO: ≥ 48 mg/mL

O=C1NC(C(F)=CN1C2OCCC2)=O

2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-

(-20℃)

With Ice Pack

≥ 2 years