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BP-897

CAS No. 314776-92-6

BP-897( BP897 )

Catalog No. M14019 CAS No. 314776-92-6

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BP-897
  • Note
    Research use only, not for human use.
  • Brief Description
    BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.
  • Description
    BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM; displays 70 times lower affinity for D2 (Ki=61 nM), low affinities for D1 and D4 (Ki= 3 and 0.3 uM) and α1 and α2 adrenergic receptor (Ki=60 and 83 nM), negligible affinities (Ki>1 uM) for muscarinic, histamine and opiate receptors; inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects.Parkinson Disease Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Listar hooded rats Dosage:0.05, 0.5, 1 mg/kg Administration:i.p.; 30 min before the session Result:Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
  • Synonyms
    BP897
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    314776-92-6
  • Formula Weight
    417.553
  • Molecular Formula
    C26H31N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (275.33 mM)
  • SMILES
    O=C(NCCCCN1CCN(C2=CC=CC=C2OC)CC1)C3=CC=C4C=CC=CC4=C3
  • Chemical Name
    N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pilla M, et al. Nature. 1999 Jul 22;400(6742):371-5. 2. Wood MD, et al. Eur J Pharmacol. 2000 Oct 27;407(1-2):47-51. 3. Wicke K, et al. Eur J Pharmacol. 2001 Jul 20;424(2):85-90.
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