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AHN 1-055 hydrochloride
CAS No. 202646-03-5
AHN 1-055 hydrochloride( 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride )
Catalog No. M28222 CAS No. 202646-03-5
AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 132 | In Stock |
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| 50MG | 198 | In Stock |
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| 100MG | 305 | In Stock |
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| 200MG | 458 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAHN 1-055 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
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DescriptionAHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.(In Vivo):In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.
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In Vitro——
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In VivoAnimal Model:Adult male Sprague Dawley rats (250-275 g)Dosage:5?mg/kg (Pharmacokinetic Analysis)Administration:I.v. administration Result:Cmax (1.48 mg/L); T1/2 (7.69 h).
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Synonyms3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorEGFR (wt)|EGFR (L858R)|EGFR (L861Q)|EGFR (L858R/T790M)
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Research Area——
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Indication——
Chemical Information
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CAS Number202646-03-5
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Formula Weight379.87
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Molecular FormulaC21H24ClF2NO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (263.25 mM)
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SMILESCN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Luwei Han, et al. SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer. Front Pharmacol. 2021 Apr 27;12:665253.
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