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Bay 41-4109 racemate
CAS No. 298708-79-9
Bay 41-4109 racemate( Bay-414109 racemate )
Catalog No. M13916 CAS No. 298708-79-9
The racemate form of Bay 41-4109, which is a potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 31 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 102 | In Stock |
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| 50MG | 174 | In Stock |
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| 100MG | 275 | In Stock |
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| 200MG | 399 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBay 41-4109 racemate
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NoteResearch use only, not for human use.
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Brief DescriptionThe racemate form of Bay 41-4109, which is a potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.
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DescriptionThe racemate form of Bay 41-4109, which is a potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.
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In VitroBAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
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In VivoBAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
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SynonymsBay-414109 racemate
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number298708-79-9
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Formula Weight395.7629296
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Molecular FormulaC18H13ClF3N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 37 mg/mL
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SMILESCC1=C(C(N=C(N1)C2=C(C=C(C=N2)F)F)C3=C(C=C(C=C3)F)Cl)C(=O)OC
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Chemical Name5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Deres K, et al. Science. 2003 Feb 7;299(5608):893-6.
2. Weber O, et al. Antiviral Res. 2002 May;54(2):69-78.
3. Brezillon N, et al. PLoS One. 2011;6(12):e25096.
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