Etidronate( —— )

Catalog No. M13855 CAS No. 2809-21-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Etidronate
Note

Research use only, not for human use.
Brief Description

Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor.
Description

Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor.(In Vitro):Etidronic acid (Etidronate) (10 mM, 24 h) shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells.Etidronic acid (100 nM, 24 h) induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.
In Vitro

Etidronic acid (Etidronate) (10 mM, 24 h) shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells.Etidronic acid (100 nM, 24 h) induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy.
In Vivo

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Synonyms

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Pathway

Microbiology/Virology
Target

HBV
Recptor

HAP| PTPase S| V-type proton ATPase catalytic subunit
Research Area

Other Indications
Indication

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1. Grases F, et al. Circ J. 2007 Jul;71(7):1152-6.

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