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Mebeverine hydrochloride
CAS No. 2753-45-9
Mebeverine hydrochloride( —— )
Catalog No. M13843 CAS No. 2753-45-9
Mebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 25MG | 35 | In Stock |
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| 50MG | 51 | In Stock |
|
| 100MG | 77 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | 170 | In Stock |
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| 1G | 269 | In Stock |
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Biological Information
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Product NameMebeverine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping.
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DescriptionMebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping. It works by relaxing the muscles in and around the gut. It is a musculotropic antispasmodic drug without anticholinergic side-effects. The drug is also indicated for treatment of gastrointestinal spasm secondary to organic disorder.(In Vitro):Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity.
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In VitroMebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2753-45-9
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Formula Weight466.01
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Molecular FormulaC25H36ClNO5
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCl.CCN(CCCCOC(=O)C1=CC(OC)=C(OC)C=C1)C(C)CC1=CC=C(OC)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Men 10376 TFA
Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
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ELA-14 (human)
Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
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8-Hydroxygenistein
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O??). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein. The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.
