Chicago Sky Blue 6B

Research use only, not for human use.

A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry.

A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry, also is the first small molecule prion protein (PrP) ligand capable of inhibiting Aβ binding; inhibits Aβ binding and reduce prion levels was established in cell-based assays; also is a competitive VGLUT inhibitor without affecting plasma membrane transporters, shows antinociceptive effects in vivo; also is an allosteric inhibitor of macrophage migration inhibitory factor (MIF) with IC50 of 0.81 uM.

Cell Cytotoxicity Assay Cell Line:BMMs Concentration:0.75, 1.5, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM Incubation Time:48, 96 h Result:Exhibited no cytotoxic effect at concentrations of 0-50 μM.Western Blot Analysis Cell Line:BMMs Concentration:5, 10, 20 μM Incubation Time:0, 1, 3, 5 days Result:Attenuated the protein expression of both c-Fos and NFATc1.Decreased the protein expression of MIF.

Animal Model:OVX-induced osteoporosis mice model Dosage:2, 8 m/kg Administration:s.c.Result:Inhibited the elevated osteoclast formation and bone resorption.Animal Model:METH-induced hyperactivity in miceDosage:7.5 μg Administration:i.c.v.Result:Reduced acute hyperactivity and attenuated expression of sensitization.

Direct Blue 1 | Pontamine sky blue | p-425 | p425

Others

Amyloids

GlutamateTransporters

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2610-05-1

992.791

C34H24N6Na4O16S4

>98% (HPLC)

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=S(C1=C2C=CC(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(O)C6=C(N)C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6C=C5)C(OC)=C4)C=C3OC)=C(O)C2=C(N)C(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+].[Na+].[Na+]

Tetrasodium;(6E)-4-amino-6-[[4-[4-[(2E)-2-(8-amino-1-oxo-5,7-disulfonatonaphthalen-2-ylidene)hydrazinyl]-3-methoxyphenyl]-2-methoxyphenyl]hydrazinylidene]-5-oxonaphthalene-1,3-disulfonate

(-20℃)

With Ice Pack

≥ 2 years