OSU-T315( OSU-T 315 )

Catalog No. M11325 CAS No. 1333146-24-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

OSU-T315
Note

Research use only, not for human use.
Brief Description

A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
Description

A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM; exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells; facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain; suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis; demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.
In Vitro

——
In Vivo

——
Synonyms

OSU-T 315
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Cancer
Indication

——

CAS Number

1333146-24-9
Formula Weight

533.5873
Molecular Formula

C30H30F3N5O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1
Chemical Name

1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

1. Lee SL, et al. J Med Chem. 2011 Sep 22;54(18):6364-74. 2.?Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.

Calculator

molnova catalog