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Home - Products - GPCR/G Protein - Antibacterial - LN-1-255

LN-1-255

CAS No. 247115-03-3

LN-1-255( LN 1-255 | LN1255 )

Catalog No. M13722 CAS No. 247115-03-3

LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LN-1-255
  • Note
    Research use only, not for human use.
  • Brief Description
    LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor.
  • Description
    LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor; inhibits SHV-1 and SHV-2 beta-lactamases with Ki of 110 nM and 100 nM, significantly enhances the activity of ceftazidime and cefpirome against extended-spectrum cephalosporin and Sme-1 containing carbapenem-resistant clinical strains; also inhibits the class D carbapenemase OXA-48 with IC50 of 3 nM, an important emerging mechanism of antibiotic resistance.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LN 1-255 | LN1255
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    247115-03-3
  • Formula Weight
    510.449
  • Molecular Formula
    C22H19N2NaO9S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-[[[(3,4-dihydroxyphenyl)acetyl]oxy]methyl]-3-methyl-7-oxo-6-(2-pyridinylmethylene)-, 4,4-dioxide, monosodium salt, (2S,3R,5R,6Z)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pattanaik P, et al. J Biol Chem. 2009 Jan 9;284(2):945-53. 2. Vallejo JA, et al. J Antimicrob Chemother. 2016 Aug;71(8):2171-80. 3. Vázquez-Ucha JC, et al. Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01172-17.
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