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Home - Products - Chromatin/Epigenetic - COX - Bufexamac

Bufexamac

CAS No. 2438-72-4

Bufexamac( Bufexamac | CP-1044-J-3 | CP 1044 J 3 | CP1044J3 | Droxaryl | Parfenac )

Catalog No. M13704 CAS No. 2438-72-4

Bufexamac is a COX inhibitor for IFN-α release.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
100MG 27 In Stock
200MG 35 In Stock
500MG 48 In Stock
1G 70 In Stock
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Biological Information

  • Product Name
    Bufexamac
  • Note
    Research use only, not for human use.
  • Brief Description
    Bufexamac is a COX inhibitor for IFN-α release.
  • Description
    Bufexamac is a COX inhibitor for IFN-α release.
  • In Vitro
    Cell Viability Assay Cell Line:BE(2)-C cells Concentration:30 μM Incubation Time:6 days Result:Enhanced cell death of tumor cells.Cell Migration Assay Cell Line:mouse neutrophils Concentration:50-100 μM Incubation Time:30 min Result:Reduced fMLP (5μM) induced neutrophil migration.Western Blot Analysis Cell Line:Hela cells (ATCC: CCL-2)Concentration:1 mM Incubation Time:4-16 hResult:Induced HIF1-α protein and increased HIF1-α levels.ImmunofluorescenceCell Line:Hela cells (ATCC: CCL-2)Concentration:50-250 μM Incubation Time:4 h Result:Stabilized HIF1-α and accumulated in the nucleus.
  • In Vivo
    Animal Model:Six-to-eight weeks old female C57BL/6 miceDosage:50-100 mg/kg Administration:Oral gavage (p.o.), seven days Result:Ameliorated the infiltration of lung inflammatory cells and injury to the lung in a dose-dependent manner.Relieved LPS-induced lung injury.Reduced LTB4 level and MPO activity.Reduced cytokine mRNA expressions in lung tissue and cytokine levels in BALF in LPS-induced ALI in mice.Animal Model:horses aged 2 to 7 years old and weighing 302 to 522 kg Dosage:20-100 mg Administration:Intraarticular (IA) injection, weekly, 6 times Result:Didn't effect on general health, hematological or serum biochemical variables, or organs.
  • Synonyms
    Bufexamac | CP-1044-J-3 | CP 1044 J 3 | CP1044J3 | Droxaryl | Parfenac
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    IFN-α
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    2438-72-4
  • Formula Weight
    223.27
  • Molecular Formula
    C12H17NO3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 3 mg/mL (13.43 mM); DMSO: 45 mg/mL (201.54 mM)
  • SMILES
    O=C(NO)CC1=CC=C(OCCCC)C=C1
  • Chemical Name
    2-(4-butoxyphenyl)-N-hydroxyacetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kr?nke B, et al. Contact Dermatitis. 1997 Apr;36(4):212-5.
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