4',7-Dihydroxyflavone

Research use only, not for human use.

4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti.

4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates.

Western Blot Analysis Cell Line:NCI-H292 cells stimulated with 10?ng/mL PMA for 30?min Concentration:2 and 10?μM Incubation Time:24?h Result:Inhibited PMA-stimulated NF-κB (p65) activation and STAT6 phosphorylation.

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7,4'-Dihydroxyflavone

Chromatin/Epigenetic

COX

COX|NOD1

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2196-14-7

254.1

C15H10O4

>98% (HPLC)

DMSO:250 mg/mL (983.32 mM)

Oc1ccc(cc1)-c1cc(=O)c2ccc(O)cc2o1

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(-20℃)

With Ice Pack

≥ 2 years