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MU1210
CAS No. 2275601-87-9
MU1210( MU-1210 | MU 1210 )
Catalog No. M13620 CAS No. 2275601-87-9
MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMU1210
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NoteResearch use only, not for human use.
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Brief DescriptionMU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM.
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DescriptionMU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1); profoundly affected the Mdm4 alternative splicing and showed high activity in cytotoxicity assays using MCF7 breast cancer cells; MU1210 has favorable pharmacokinetics (mouse, 10 mpk, IP: Cmax =1.24 mm, T1/2 = 58 min; no acute toxicity observed), suggesting its potential use in in vivo models; MU1210 is a quality probe for CLK1, CLK2, and CLK4.
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In Vitro——
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In Vivo——
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SynonymsMU-1210 | MU 1210
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research Area——
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Indication——
Chemical Information
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CAS Number2275601-87-9
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Formula Weight352.397
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Molecular FormulaC22H16N4O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.
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