ZL0420( ZL-0420 | ZL 0420 )

Catalog No. M13567 CAS No. 2229039-45-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ZL0420
Note

Research use only, not for human use.
Brief Description

ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
Description

ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.
In Vitro

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In Vivo

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Synonyms

ZL-0420 | ZL 0420
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

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Indication

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CAS Number

2229039-45-4
Formula Weight

296.33
Molecular Formula

C16H16N4O2
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=C(O)C=C(N)C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)=C1
Chemical Name

(E)-6-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one

1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151. 2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461.

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