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SB408124
CAS No. 288150-92-5
SB408124( —— )
Catalog No. M17465 CAS No. 288150-92-5
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | Get Quote |
|
| 10MG | 73 | Get Quote |
|
| 25MG | 162 | Get Quote |
|
| 50MG | 291 | Get Quote |
|
| 100MG | 431 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSB408124
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NoteResearch use only, not for human use.
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Brief DescriptionSB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
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DescriptionSB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
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In Vitro——
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In VivoSB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats.
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorOX1 (membrane)| OX1 (whole cell)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number288150-92-5
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Formula Weight356.37
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Molecular FormulaC19H18F2N4O
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 140.30 mM; H2O : < 0.1 mg/mL
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SMILESCN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Langmead CJ, et al, Br J Pharmacol, 2004, 141(2) , 340-346.
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