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SB408124

CAS No. 288150-92-5

SB408124( —— )

Catalog No. M17465 CAS No. 288150-92-5

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 56 In Stock
5MG 38 In Stock
10MG 61 In Stock
25MG 121 In Stock
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Biological Information

  • Product Name
    SB408124
  • Note
    Research use only, not for human use.
  • Brief Description
    SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
  • Description
    SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
  • In Vitro
    ——
  • In Vivo
    SB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    OX1 (membrane)| OX1 (whole cell)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    288150-92-5
  • Formula Weight
    356.37
  • Molecular Formula
    C19H18F2N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 140.30 mM; H2O : < 0.1 mg/mL
  • SMILES
    CN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Langmead CJ, et al, Br J Pharmacol, 2004, 141(2) , 340-346.
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