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Hydroxyzine dihydrochloride
CAS No. 2192-20-3
Hydroxyzine dihydrochloride( —— )
Catalog No. M13496 CAS No. 2192-20-3
Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | 27 | In Stock |
|
| 500MG | 33 | In Stock |
|
| 1G | 45 | In Stock |
|
Biological Information
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Product NameHydroxyzine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionHydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.
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DescriptionHydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.(In Vitro):Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.(In Vivo):Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
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In VitroHydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
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In VivoHydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH1 receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number2192-20-3
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Formula Weight447.83
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Molecular FormulaC21H27ClN2O2·2HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 15 mg/mL (33.49 mM); Water: 90 mg/mL (200.96 mM); DMSO: 90 mg/mL (200.96 mM)
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SMILESCl.Cl.OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Anthes JC, et al. Eur J Pharmacol, 2002, 449(3), 229-237.
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