BI-3812( BI3812 | BI 3812 )

Catalog No. M13458 CAS No. 2166387-64-8

COA

Datasheet

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Product Name

BI-3812
Note

Research use only, not for human use.
Brief Description

A highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
Description

A highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 40 nM in vitro.
In Vitro

——
In Vivo

——
Synonyms

BI3812 | BI 3812
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

——

CAS Number

2166387-64-8
Formula Weight

558.036
Molecular Formula

C26H32ClN7O5
Purity

>98% (HPLC)
Solubility

DMSO : 20.83 mg/mL 37.33 mM; H2O : < 0.1 mg/mL
SMILES

O=C(C1CCN(C2=NC=C(Cl)C(NC3=CC4=C(N(C)C(C(OCC(NC)=O)=C4)=O)C(OC)=C3)=N2)CC1)N(C)C
Chemical Name

1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.

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