LSD1-IN-32( —— )

Catalog No. M13404 CAS No. 2137044-49-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LSD1-IN-32
Note

Research use only, not for human use.
Brief Description

LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM.
Description

LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

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Indication

——

CAS Number

2137044-49-4
Formula Weight

422.504
Molecular Formula

C24H27FN4O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-[[2-(2,7-Diazaspiro[3.5]nonan-7-yl)-2-oxo-ethyl]-[(3-fluoro-4-methoxy-phenyl)methyl]amino]benzonitrile

1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999.

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