FXR-sHE modulator 57( —— )

Catalog No. M13389 CAS No. 2129523-23-3

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Product Name

FXR-sHE modulator 57
Note

Research use only, not for human use.
Brief Description

A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
Description

A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4); demonstrates antisteatotic and antifibrotic effects and potential for nonalcoholic steatohepatitis (NASH) management with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics.
In Vitro

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In Vivo

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Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

FXR
Recptor

FXR
Research Area

——
Indication

——

CAS Number

2129523-23-3
Formula Weight

394.914
Molecular Formula

C19H23ClN2O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-(tert-Butyl)-N-(2-chloro-4-(methylsulfonamido)benzyl)-benzamide

1. Schmidt J, et al. J Med Chem. 2017 Sep 28;60(18):7703-7724.

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