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WHI-P154

CAS No. 211555-04-3

WHI-P154( JAK3 Inhibitor II | Janus-Associated Kinase 3 Inhibitor II )

Catalog No. M13364 CAS No. 211555-04-3

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	55	In Stock
2MG	33	In Stock
5MG	53	In Stock
10MG	84	In Stock
25MG	176	In Stock
50MG	325	In Stock
100MG	527	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

WHI-P154
Note

Research use only, not for human use.
Brief Description

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
Description

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
In Vitro

——
In Vivo

——
Synonyms

JAK3 Inhibitor II | Janus-Associated Kinase 3 Inhibitor II
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR| JAK3| Src| VEGFR
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

211555-04-3
Formula Weight

376.2
Molecular Formula

C16H14BrN3O3
Purity

>98% (HPLC)
Solubility

DMSO: 75 mg/mL (199.36 mM)
SMILES

OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br
Chemical Name

2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.O'Donoghue ML, et al. J Thromb Thrombolysis. 2012 Jul;34(1):36-43.

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