CM03

Research use only, not for human use.

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine.

CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1.CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines.Western Blot Analysis Cell Line:MIA PaCa-2 and PANC-1 Concentration:0.4 μM Incubation Time:24 h for MIA PaCa-2, 48 h for PANC-1Result:Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).Cell Proliferation Assay Cell Line:MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 Concentration:0-100 nM Incubation Time:96 h Result:Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI50s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.

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G-quadruplex binder CM03

Cell Cycle/DNA Damage

DNA Alkylator

DNA Alkylator

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2101208-44-8

632.762

C34H44N6O6

>98% (HPLC)

In Vitro:?DMSO : 2 mg/mL (3.16 mM)

O=C(N(CCCN1CCOCC1)C(C2=C3C4=C(C(N5CCCN6CCOCC6)=O)C=C2NCCN7CCCC7)=O)C3=CC=C4C5=O

2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone

(-20℃)

With Ice Pack

≥ 2 years