BRD4 degrader AT1( BRD4 PROTAC AT1 )

Catalog No. M13321 CAS No. 2098836-45-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BRD4 degrader AT1
Note

Research use only, not for human use.
Brief Description

BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
Description

BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
In Vitro

——
In Vivo

——
Synonyms

BRD4 PROTAC AT1
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

Cancer
Indication

——

CAS Number

2098836-45-2
Formula Weight

972.68
Molecular Formula

C48H58ClN9O5S3
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 102.81 mM
SMILES

CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(C)=O)C(C)(SCCCCCCNC(C[C@H]4C5=NN=C(C)N5C(SC(C)=C6C)=C6C(C7=CC=C(Cl)C=C7)=N4)=O)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
Chemical Name

(2S,4R)-1-((R)-2-acetamido-3-((6-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)hexyl)thio)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

1. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

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