Cart
sales@molnova.com
SNIPER(ABL)-062
CAS No. 2140260-89-3
SNIPER(ABL)-062( SNIPER ABL 062 )
Catalog No. M13419 CAS No. 2140260-89-3
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSNIPER(ABL)-062
-
NoteResearch use only, not for human use.
-
Brief DescriptionSNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
-
DescriptionSNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation; shows desirable binding affinities against ABL1, cIAP1/2, and XIAP (IC50=80-500 nM), inhibits BCR-ABL-mediated signaling pathways and CML proliferation in cells expressing BCR-ABL.
-
In Vitro——
-
In Vivo——
-
SynonymsSNIPER ABL 062
-
PathwayPROTACs
-
TargetPROTAC
-
RecptorPROTAC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2140260-89-3
-
Formula Weight1089.655
-
Molecular FormulaC53H63ClF2N10O9S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC(=CC=C4)OCCOCCOCCNC(=O)C5CCN(C5)C6=C(C=C(C=N6)C(=O)NC7=CC=C(C=C7)OC(F)(F)Cl)C8=CC=NN8)NC
-
Chemical NameN-(4-(chlorodifluoromethoxy)phenyl)-6-(3-((2-(2-(2-(3-(2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethyl)carbamoyl)pyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shimokawa K, et al. ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047.
molnova catalog
related products
-
Lenalidomide-Br
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
-
DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry.?The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.?PEG Linkers can be used in the synthesis of PROTACs.
-
CDK9-PROTAC
CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.
