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Sirt2-PROTAC-1
CAS No. 2098487-75-1
Sirt2-PROTAC-1( Sirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1 )
Catalog No. M13316 CAS No. 2098487-75-1
A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSirt2-PROTAC-1
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NoteResearch use only, not for human use.
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Brief DescriptionA novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
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DescriptionA novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
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In VitroWestern Blot Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1-6 hours Result:Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
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In Vivo——
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SynonymsSirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2098487-75-1
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Formula Weight852.942
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Molecular FormulaC40H40N10O8S2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 117.24 mM; H2O : < 0.1 mg/mL
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SMILESO=C(NC1=NC=C(CC2=CC=CC(OCC3=CN(CCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)N=N3)=C2)S1)CSC7=NC(C)=CC(C)=N7
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Chemical Name2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ac4GalNAz
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry.?The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.?PEG Linkers can be used in the synthesis of PROTACs.
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m-PEG24-NH2
m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
