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PF-DcpSi
CAS No. 2092917-19-4
PF-DcpSi( —— )
Catalog No. M13280 CAS No. 2092917-19-4
A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-DcpSi
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
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DescriptionA potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.Spinal Muscular Atrophy (SMA)Preclinical.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaNeurological Disease
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IndicationSpinal Muscular Atrophy(SMA)
Chemical Information
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CAS Number2092917-19-4
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Formula Weight309.304
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Molecular FormulaC16H12FN5O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=CC(=CC(=C3)C#N)F
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Chemical Name3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. J Med Chem. 2017 Apr 13;60(7):3094-3108.
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