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PF-DcpSi

CAS No. 2092917-19-4

PF-DcpSi( —— )

Catalog No. M13280 CAS No. 2092917-19-4

A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-DcpSi
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM).
  • Description
    A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.Spinal Muscular Atrophy (SMA)Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Neurological Disease
  • Indication
    Spinal Muscular Atrophy(SMA)

Chemical Information

  • CAS Number
    2092917-19-4
  • Formula Weight
    309.304
  • Molecular Formula
    C16H12FN5O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=C2C(=C1)N=C(N=C2N)N)COC3=CC(=CC(=C3)C#N)F
  • Chemical Name
    3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. J Med Chem. 2017 Apr 13;60(7):3094-3108.
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