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ML167
CAS No. 1285702-20-6
ML167( ML-167 | ML 167 )
Catalog No. M11167 CAS No. 1285702-20-6
A potent, selective CDC-like kinase 4 (CLK4) inhibitor with IC50 of 136 nM, >10-fold selectivity over Clk1, Clk2, Clk3, Dyrk1A/1B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 2MG | 28 | In Stock |
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| 5MG | 40 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 138 | In Stock |
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| 50MG | 230 | In Stock |
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| 100MG | 342 | In Stock |
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| 200MG | 486 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML167
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective CDC-like kinase 4 (CLK4) inhibitor with IC50 of 136 nM, >10-fold selectivity over Clk1, Clk2, Clk3, Dyrk1A/1B.
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DescriptionA potent, selective CDC-like kinase 4 (CLK4) inhibitor with IC50 of 136 nM, >10-fold selectivity over Clk1, Clk2, Clk3, Dyrk1A/1B.
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In VitroML167 has cell permeability in Caco-2 cells. ML167 contains a furan ring which liable to in vivo metabolism.
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In Vivo——
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SynonymsML-167 | ML 167
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK1|CLK2|CLK4|Dyrk1B
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1285702-20-6
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Formula Weight335.363
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Molecular FormulaC19H17N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: 62 mg/mL (184.9 mM); Ethanol: 11 mg/mL (32.8 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESOCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1
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Chemical Name5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively; moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
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T-025
T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.
