Amifostine( Amifostine )

Catalog No. M13186 CAS No. 20537-88-6

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Product Name

Amifostine
Note

Research use only, not for human use.
Brief Description

Amifostine is a cytoprotective adjuvant used in Y chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents.
Description

Amifostine is a cytoprotective adjuvant used in Y chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents.
In Vitro

——
In Vivo

Animal Model:Male C57BL/6 mice with myocardial I/R injury Dosage:400 mg/kg Administration:Intravenous injection; 4 hours Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS. Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
Synonyms

Amifostine
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

——

CAS Number

20537-88-6
Formula Weight

214.22
Molecular Formula

C5H15N2O3PS
Purity

>98% (HPLC)
Solubility

Soluble in Water
SMILES

NCCCNCCSP(O)(O)=O
Chemical Name

2-((3-Aminopropyl)amino)-ethanethiol, dihydrogen phosphate ester (9CI)

1.Kouvaris JR. Oncologist. 12 (6): 738–47

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