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sHNG, [Gly14] - HN, [Gly14] – Humanin
CAS No. 330936-70-4
sHNG, [Gly14] - HN, [Gly14] – Humanin( ——— )
Catalog No. M41854 CAS No. 330936-70-4
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamesHNG, [Gly14] - HN, [Gly14] – Humanin
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NoteResearch use only, not for human use.
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Brief Description(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
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Description(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.
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In VitroCell Viability Assay Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:100 nM, 1 μM and 10 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Significantly increased cell viability.Western Blot Analysis Cell Line:Human umbilical vein endothelial cells (HUVECs)，Concentration:1 μM Incubation Time:Pretreatment 3 hours and then treated with 72 hours Result:Reduced the ratio of bax/bcl-2.
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In VivoAnimal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI) Dosage:0.1 μg/5 μL Administration:Intracerebroventricularly (i.c.v.); once Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number330936-70-4
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Formula Weight2657.25
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Molecular FormulaC118H202N34O31S2
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ying Xie, et al. Protection effect of Gly14-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. ?
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