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BTX161

CAS No. 2052301-24-1

BTX161( BTX-161 )

Catalog No. M13185 CAS No. 2052301-24-1

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53.

Purity : >98% (HPLC)

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Datasheet

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HPLC

MSDS

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Biological Information

Product Name

BTX161
Note

Research use only, not for human use.
Brief Description

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53.
Description

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2; upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression.
In Vitro

——
In Vivo

——
Synonyms

BTX-161
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

Casein Kinase
Research Area

——
Indication

——

Chemical Information

CAS Number

2052301-24-1
Formula Weight

272.304
Molecular Formula

C15H16N2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (91.81 mM)
SMILES

CC1=C2CN(C(=O)C2=CC=C1)C3CCCC(=O)NC3=O
Chemical Name

(S)-3-(4-methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Minzel W, et al. Cell. 2018 Aug 20. pii: S0092-8674(18)30973-5. doi: 10.1016/j.cell.2018.07.045.

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