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HDAC6-AR-IN-10
CAS No. 2042519-10-6
HDAC6-AR-IN-10( —— )
Catalog No. M13176 CAS No. 2042519-10-6
HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHDAC6-AR-IN-10
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NoteResearch use only, not for human use.
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Brief DescriptionHDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM.
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DescriptionHDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM); inhibits AR signaling and reduces the AR protein levels in LNCaP cells; a useful tool compound in pharmacology studies to evaluate the value of dual inhibition of AR and HDAC6.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2042519-10-6
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Formula Weight579.571
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Molecular FormulaC26H25F4N5O4S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-(6-(hydroxyamino)-6-oxohexyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jadhavar PS, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228.
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