HBV Capsid inhibitor 3711( Compound 3711 )

Catalog No. M13173 CAS No. 2041072-40-4

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Product Name

HBV Capsid inhibitor 3711
Note

Research use only, not for human use.
Brief Description

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor.
Description

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain.
In Vitro

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In Vivo

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Synonyms

Compound 3711
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

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Indication

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CAS Number

2041072-40-4
Formula Weight

367.833
Molecular Formula

C20H18ClN3O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-(4-(1-(4-chlorobenzyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)acetamide

1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277. 2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72.

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