Clofazimine

Research use only, not for human use.

Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

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Animal Model:Female BALB/c mice (age 6–8 weeks, mass 18–20 g)Dosage:100, 50, 25, 12.5, 6.25, 3.125 or 1.5625 mg/kgAdministration:Oral gavage (p.o.), once per day for 14 dResult:Exhibited an increase of the lung bacterial load during the first 7 days of treatment, and decreased the CFU counts in the lungs of mice after 10 days of treatment. Significantly declined the lung CFU counts in 100 or 50 mg/ kg group at 14th day.

NSC 141046

Cell Cycle/DNA Damage

DNA Alkylator

DNA| CzcO-like

Infection

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2030-63-9

473.4

C27H22Cl2N4

>98% (HPLC)

DMSO: 5 mg/mL (10.56 mM)

CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl

N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine

(-20℃)

With Ice Pack

≥ 2 years