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Revaprazan

CAS No. 199463-33-7

Revaprazan( SB-641257 | YH-1885 )

Catalog No. M13113 CAS No. 199463-33-7

Revaprazan (SB-641257;YH-1885) is a potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Revaprazan
  • Note
    Research use only, not for human use.
  • Brief Description
    Revaprazan (SB-641257;YH-1885) is a potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner.
  • Description
    Revaprazan (SB-641257;YH-1885) is a potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner; reduces gastric acid secretion, also exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling.UlcerApproved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB-641257 | YH-1885
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Proton Pump
  • Recptor
    Proton Pump
  • Research Area
    Other Indications
  • Indication
    Ulcer

Chemical Information

  • CAS Number
    199463-33-7
  • Formula Weight
    362.44
  • Molecular Formula
    C22H23FN4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1N(C2=C(C)C(C)=NC(NC3=CC=C(F)C=C3)=N2)CCC4=C1C=CC=C4
  • Chemical Name
    N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li H, et al. Drug Metab Dispos. 2001 Jan;29(1):54-9. 2. Lee JS, et al. J Clin Biochem Nutr. 2012 Sep;51(2):77-83. 3. Inatomi N, et al. Pharmacol Ther. 2016 Dec;168:12-22.
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