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Windorphen

CAS No. 19881-70-0

Windorphen( —— )

Catalog No. M13107 CAS No. 19881-70-0

A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM).

Purity : >98% (HPLC)

COA

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HPLC

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Biological Information

Product Name

Windorphen
Note

Research use only, not for human use.
Brief Description

A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM).
Description

A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM); displays >10-fold selectivity over other histone acetyltransferases; inhibits Wnt3a-inducible TOPFLASH-luciferase activity with IC50 of 1.5 uM, exhibits remarkable specificity toward β-catenin-1 function and selectively blocks the Wnt signal required for ventral development; robustly and selectively kills cancer cells that harbor Wnt-activating mutations.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

HAT
Recptor

HAT
Research Area

——
Indication

——

Chemical Information

CAS Number

19881-70-0
Formula Weight

302.75
Molecular Formula

C17H15ClO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (206.44 mM)
SMILES

COC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C=O
Chemical Name

(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hao J, et al. Cell Rep. 2013 Sep 12;4(5):898-904.

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