TH1834

Research use only, not for human use.

TH1834 (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.

TH1834 (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor; induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine; increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR; induces apoptosis and increases unrepaired DNA damage in breast cancer cells.

Cell Viability Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Significantly reduced the viability of MCF7 cells.Cell Cytotoxicity Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Highly significant increase in cytotoxicity at all concentrations used.Western Blot AnalysisCell Line:MCF7 cells Concentration:500 μMIncubation Time:1 hour Result:Marked caspase 3 activation was observed in MCF7 cells in an independent assay.

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TH-1834 | TH 1834

Chromatin/Epigenetic

HAT

HAT

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2108830-08-4

568.722

C33H40N6O3

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (17.58 mM)

C1CCN(C1)CC2=CC=C(C=C2)OCCCCN(CCC3=CC=CC=C3)CC4=CC=C(C=C4)C5=NN(N=N5)CC(=O)O

2-(5-(4-((phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid

(-20℃)

With Ice Pack

≥ 2 years