TH1834( TH-1834 | TH 1834 )

Catalog No. M13350 CAS No. 2108830-08-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

TH1834
Note

Research use only, not for human use.
Brief Description

TH1834 (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor.
Description

TH1834 (TH-1834, TH 1834) is a novel potent specific histone acetyltransferase Tip60 inhibitor; induces apoptosis in breast cancer cell lines with more cytotoxicity than staurosporine; increases the γH2AX foci in the cancer cell lines PC-3 and DU-145 combined with IR; induces apoptosis and increases unrepaired DNA damage in breast cancer cells.
In Vitro

Cell Viability Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Significantly reduced the viability of MCF7 cells.Cell Cytotoxicity Assay Cell Line:MCF7 cells Concentration:0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM Incubation Time:1 hour Result:Highly significant increase in cytotoxicity at all concentrations used.Western Blot AnalysisCell Line:MCF7 cells Concentration:500 μMIncubation Time:1 hour Result:Marked caspase 3 activation was observed in MCF7 cells in an independent assay.
In Vivo

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Synonyms

TH-1834 | TH 1834
Pathway

Chromatin/Epigenetic
Target

HAT
Recptor

HAT
Research Area

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Indication

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CAS Number

2108830-08-4
Formula Weight

568.722
Molecular Formula

C33H40N6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 10 mg/mL (17.58 mM)
SMILES

C1CCN(C1)CC2=CC=C(C=C2)OCCCCN(CCC3=CC=CC=C3)CC4=CC=C(C=C4)C5=NN(N=N5)CC(=O)O
Chemical Name

2-(5-(4-((phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid

1. Gao C, et al. Sci Rep. 2014 Jun 20;4:5372.

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