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Loxapine

CAS No. 1977-10-2

Loxapine( Adasuve | AZ-004 | CL 62,362 | Cloxazepine | Dibenzacepin | Dibenzoazepine | HF 3170 | HF3170 )

Catalog No. M13090 CAS No. 1977-10-2

A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 72 In Stock
50MG 45 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    Loxapine
  • Note
    Research use only, not for human use.
  • Brief Description
    A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.
  • Description
    A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.Schizophrenia Approved.
  • In Vitro
    In the presence of Loxapine, [3H]ketanserin binds to 5-HT2 receptor in Frontal cortex of brain in human and bovine with Ki value of 6.2 nM and 6.6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5-HT2≥D4>>>D1>D2 in comparing competition experiments involving the human membranes.Loxapine (0-20 μM, 24 h or 72 h) reduces IL-1β secretion by LPS-activated mixed glia cultures, reduces IL-2 secretion in mixed glia cultures, and decreases IL-1β and IL-2 secretion in LPS-induced microglia cultures.
  • In Vivo
    ——
  • Synonyms
    Adasuve | AZ-004 | CL 62,362 | Cloxazepine | Dibenzacepin | Dibenzoazepine | HF 3170 | HF3170
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1977-10-2
  • Formula Weight
    327.808
  • Molecular Formula
    C18H18ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1
  • Chemical Name
    Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Singh AN, et al. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. 2. Labuzek K, et al. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. 3. Lee T, et al. Psychiatry Res. 1984 Aug;12(4):277-85.
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