Cart
sales@molnova.com
AP1903
CAS No. 195514-63-7
AP1903( Rimiducid | AP-1903 )
Catalog No. M13061 CAS No. 195514-63-7
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 187 | In Stock |
|
| 5MG | 301 | In Stock |
|
| 10MG | 444 | In Stock |
|
| 25MG | 730 | In Stock |
|
| 50MG | 1004 | In Stock |
|
| 100MG | 1349 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAP1903
-
NoteResearch use only, not for human use.
-
Brief DescriptionAP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.
-
DescriptionAP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM; displaces the Fluoresceinated FK506 probe from F36V-FKBP with an IC50 of 5 nM, but shows negligible binding activity to the wild-type protein; elicited potent and dose-dependent apoptotic death of human fibrosarcoma line HT1080 expressing dimerizer-dependent Fas constructs with EC50 of 0.1 nM; induces activation of Fas signaling both in vitro and in vivo, AP1903 is a lipid-permeant dimerizing ligand induced oligomerization and activation of FKBP.Blood Cancer Phase 3 Clinical
-
In Vitro——
-
In Vivo——
-
SynonymsRimiducid | AP-1903
-
PathwayOthers
-
TargetOther Targets
-
RecptorOther Targets
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number195514-63-7
-
Formula Weight1411.65
-
Molecular FormulaC78H98N4O20
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 54 mg/mL 38.25 mM
-
SMILESO=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@H]5N(C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)CCCC5)=O)CCC7=CC=C(OC)C(OC)=C7)=C4)=O)=O)=C3)CCC8=CC=C(OC)C(OC)=C8
-
Chemical Name(S,2R,2'R)-(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Ac-Arg-Gly-Lys-AMC
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal.
-
3X FLAG peptide TFA ...
The 3X FLAG Peptide is a synthetic peptide of 23 amino acid residue. The Asp-Tyr-Lys-Xaa-Xaa-Asp motif is repeated three times in the peptide.
-
ND-646
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively)ND-646-an allosteric inhibitor of the ACC enzymes. ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.?
