Otamixaban( FXV-673 )

Catalog No. M13026 CAS No. 193153-04-7

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Otamixaban
Note

Research use only, not for human use.
Brief Description

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM.
Description

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM; shows >1,000-fold selectivity over thrombin, activated protein C (aPC), plasmin, and tissue-plasminogen activator (t-PA); dose-dependently prolongs the time to vessel occlusion and inhibits thrombus formation in canine models of thrombosis.Thrombosis Phase 3 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

FXV-673
Pathway

Metabolic Enzyme/Protease
Target

Factor Xa
Recptor

Factor Xa
Research Area

Cardiovascular Disease
Indication

Thrombosis

Chemical Information

CAS Number

193153-04-7
Formula Weight

446.4984
Molecular Formula

C25H26N4O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C[C@@H](NC(C1=CC=C(C2=CC=[N+]([O-])C=C2)C=C1)=O)[C@@H](CC3=CC=CC(C(N)=N)=C3)C(OC)=O
Chemical Name

Benzenepropanoic acid, 3-(aminoiminomethyl)-.alpha.-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]-, methyl ester, (.alpha.R)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Guertin KR, et al. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4. 2. Chu V, et al. Thromb Res. 2001 Aug 15;103(4):309-24. 3. Rebello SS, et al. J Cardiovasc Pharmacol. 2001 Aug;38(2):288-97.

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