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Letaxaban
CAS No. 870262-90-1
Letaxaban( TAK-442 | TAK442 )
Catalog No. M16321 CAS No. 870262-90-1
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 359 | In Stock |
|
| 10MG | 518 | In Stock |
|
| 25MG | 785 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLetaxaban
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NoteResearch use only, not for human use.
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Brief DescriptionLetaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa.
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DescriptionLetaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA; In human plasma, TAK-442 doubles FXa-induced clotting time, prothrombin time (PT), and activated partial thromboplastin time at 0.19, 0.55, and 0.59 uM, respectively; demonstrates antithrombotic effects in rabbit model of venous thrombosis.Thrombosis Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTAK-442 | TAK442
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PathwayMetabolic Enzyme/Protease
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TargetFactor Xa
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RecptorFactor Xa
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number870262-90-1
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Formula Weight479.98
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Molecular FormulaC22H26ClN3O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NCCCN1C2CCN(C([C@H](O)CS(=O)(C3=CC=C4C=C(Cl)C=CC4=C3)=O)=O)CC2
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Chemical Name(S)-1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kawamura M, et al. J Cardiovasc Pharmacol. 2010 Aug;56(2):156-61.
2. Konishi N, et al. Thromb Res. 2010 Aug;126(2):124-9.
3. Konishi N, et al. Thromb Haemost. 2010 Sep;104(3):504-13.
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