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ST-162
CAS No. 1883817-83-1
ST-162( ST162 )
Catalog No. M12936 CAS No. 1883817-83-1
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameST-162
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NoteResearch use only, not for human use.
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Brief DescriptionST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.
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DescriptionST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively; produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas; increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1.
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In Vitro——
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In Vivo——
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SynonymsST162
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1883817-83-1
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Formula Weight982.752
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Molecular FormulaC40H44F5IN10O6
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(2-(2-(2-(2-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Galbán S, et al. Mol Cancer Ther. 2017 Nov;16(11):2340-2350.
2. Van Dort ME, et al. J Med Chem. 2016 Mar 24;59(6):2512-22.
3. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.
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