YIR-819 TFA salt( YIR819 )

Catalog No. M12923 CAS No. 1883372-87-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

YIR-819 TFA salt
Note

Research use only, not for human use.
Brief Description

YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
Description

YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM); A useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.
In Vitro

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In Vivo

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Synonyms

YIR819
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

1883372-87-9
Formula Weight

606.044
Molecular Formula

C25H35ClF3N7O5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N1-(4-chlorophenyl)-N2-(1-(2-(2-guanidinoacetamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide TFA salt

1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6. 2. Boonstra A, et al. Antivir Ther. 2012;17(4):657-67.

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