iCRT-5( iCRT5 )

Catalog No. M12878 CAS No. 18623-44-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

iCRT-5
Note

Research use only, not for human use.
Brief Description

iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.
Description

iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM; specifically modulates the nuclear transcriptional activity of β-catenin while not affecting its cytoskeletal function in stabilizing adherens junctions at the cell membrane; blocks Wnt/β-catenin-induced target genes and phenotypes in various mammalian and cancer cell lines.
In Vitro

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In Vivo

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Synonyms

iCRT5
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

——
Indication

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CAS Number

18623-44-4
Formula Weight

367.44
Molecular Formula

C16H17NO5S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 36 mg/mL (97.98 mM)
SMILES

O=C(O)CCCN(C/1=O)C(SC1=C/C2=CC=C(OC)C(OC)=C2)=S
Chemical Name

(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid

1. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63. 2. Anastas JN, et al. Nat Rev Cancer. 2013 Jan;13(1):11-26.

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