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SirReal2 (b)
CAS No. 1848251-24-0
SirReal2 (b)( MZ25 | MZ-25 | SirReal 2 )
Catalog No. M12854 CAS No. 1848251-24-0
SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSirReal2 (b)
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NoteResearch use only, not for human use.
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Brief DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
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DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.
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In Vitro——
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In Vivo——
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SynonymsMZ25 | MZ-25 | SirReal 2
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research Area——
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Indication——
Chemical Information
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CAS Number1848251-24-0
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Formula Weight420.549
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Molecular FormulaC22H20N4OS2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C
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Chemical Name2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263.
2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.
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