CM-579( CM579 | CM 579 )

Catalog No. M12853 CAS No. 1846570-40-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CM-579
Note

Research use only, not for human use.
Brief Description

CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
Description

CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively; also inhibits DNMT3A/3B with IC50 of 92/1,000 nM, respectively; inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).
In Vitro

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively.
In Vivo

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Synonyms

CM579 | CM 579
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

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CAS Number

1846570-40-8
Formula Weight

492.664
Molecular Formula

C29H40N4O3
Purity

>98% (HPLC)
Solubility

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SMILES

COC1=C(OCCCN2CCCC2)C=C(N=C(C3=CC=C(C)O3)C=C4NC5CCC[N]C5)C4=C1
Chemical Name

6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.

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