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CM-579
CAS No. 1846570-40-8
CM-579( CM579 | CM 579 )
Catalog No. M12853 CAS No. 1846570-40-8
CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
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| 10MG | 127 | Get Quote |
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| 25MG | 206 | Get Quote |
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| 50MG | 302 | Get Quote |
|
| 100MG | 446 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCM-579
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NoteResearch use only, not for human use.
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Brief DescriptionCM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
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DescriptionCM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively; also inhibits DNMT3A/3B with IC50 of 92/1,000 nM, respectively; inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).
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In VitroThe Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively.
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In Vivo——
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SynonymsCM579 | CM 579
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number1846570-40-8
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Formula Weight492.664
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Molecular FormulaC29H40N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=C(OCCCN2CCCC2)C=C(N=C(C3=CC=C(C)O3)C=C4NC5CCC[N]C5)C4=C1
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Chemical Name6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.
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