UNC0321( UNC 0321 | UNC-0321 )

Catalog No. M10957 CAS No. 1238673-32-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

UNC0321
Note

Research use only, not for human use.
Brief Description

A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.
Description

A highly potent, selective G9a inhibitor with Ki of 63 pM; inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays; dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4 uM); but lacks sufficient cellular potency.
In Vitro

Western Blot AnalysisCell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Reduced glucose induced expression of Cleared Caspase3 and Bax.Relieved the inhibition of glucose on Bcl-2, Caspase3, p-AKT, p-mTOR and p70 expression.Promoted proliferation and inhibited apoptosis by inhibiting Rab4. Apoptosis Analysis Cell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Inhibited glucose induced apoptosis.Cell Proliferation Assay Cell Line:HUVEC.Concentration:50 pM, 100 pM, 200 pM.Incubation Time:48 h.Result:Relieved the inhibition of glucose on HUVEC proliferation.
In Vivo

——
Synonyms

UNC 0321 | UNC-0321
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Other Indications
Indication

——

CAS Number

1238673-32-9
Formula Weight

515.6913
Molecular Formula

C27H45N7O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

CN1CCC(NC2=C3C=C(OC)C(OCCOCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1
Chemical Name

4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-

1. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57. 2. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.

Calculator

molnova catalog