CPI 0610( CPI0610 )

Catalog No. M12851 CAS No. 1845726-14-8

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Datasheet

HNMR

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Product Name

CPI 0610
Note

Research use only, not for human use.
Brief Description

CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
Description

CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay; shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8; has an IC50 of 0.18 uM in MYC RNA expression assay; demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.
In Vitro

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In Vivo

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Synonyms

CPI0610
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

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Indication

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CAS Number

1845726-14-8
Formula Weight

365.817
Molecular Formula

C20H16ClN3O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[e]isoxazolo[5,4-c]azepin-4-yl)acetamide

1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9. 2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355.

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